Biotin Interference with Immunoassays

Biotin is a coenzyme and a B vitamin that occurs naturally in many foods. Wheat germ, whole-grain cereals, whole wheat bread, eggs, dairy products, peanuts, soya nuts, Swiss chard, salmon, and chicken are all sources of biotin. The Institute of Medicine recommends a daily intake of 30 mcg for adults.

In spite of this official recommendation, many people have begun taking high dose biotin supplements because of marketing claims that it can strengthen keratin and improve hair, nails, and skin. These supplements may be labeled as vitamin B7, vitamin H, or coenzyme R and contain more than 300 times the recommended daily dose. For example, Costco sells Kirkland Signature Hair Skin and Nails that contains 5000 mcg of biotin per pill. Sam’s Club sells Members Mark Biotin 1000 mcg with Keratin 100 mg. Other popular brands are Nature’s Bounty Hair Skin and Nails and Natrol Biotin.

In January 2016, the Endocrine Society alerted its members that mega doses of biotin could interfere with immunoassays that incorporate biotin and streptavidin into their immunoassay design. Biotin interference can produce either falsely high or low results, depending on immunoassay format. In general, biotin causes falsely high results in competitive immunoassays and falsely low results in immunometric immunoassays. The degree of interference may vary by immunoassay manufacturer.

In September 2016, CAP had an article to confirm the Biotin interference and list of laboratories and laboratory equipment manufactures that are effected with this important findings.

CAP article can be read above, under “see details”.

As part of our commitment to our patients and providers in delivering the most accurate results, we are proud to announce that our platforms do not have Biotin interference.

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